CAR-T AUC distributions. The box plot labeled Kymriah shows the distribution in AUC obtained from 1,000 simulations of the clinical pharmacokinetics model (each dot corresponds to a percentile of the AUC distribution). The group of box plots labeled Model shows the AUC distribution obtained for the 12 best-fitting parameter sets for each population (CR, blue; PR, gray; NR, pink) with the colored background the range of AUCs obtained from the clinical pharmacokinetics data. The group of box plots labeled +Dose shows the AUC distributions for each population when doses are randomized within reported ranges in the virtual population ( n = 1,000); +B0 shows the distributions when initial tumor burdens are randomized; and +Dose/B0 shows the distribution when both dose and initial tumor burdens are randomized. Box plots represent median 25th percentiles and whiskers the min/max value or an additional 1.5-fold quartile distance.
