Bubble Plot from Scientific Research

CAR-T response scorecard, representing the 28 gene signatures fed into the transcriptome classifier, ordered by differential GSEA in Fraietta et al. 18. Bubble size indicates frequency of inclusion in the 2,500 trained models after feature selection; color indicates differential enrichment between response groups by dataset, based on pseudo-bulked GSEA (score = -1 x sign(NES) x log 10 P value). Red, CR enriched; blue, NR/PR/RL enriched. Gene signatures are annotated by source. NES, normalized enrichment score.

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