Line Plot from Scientific Research

We fit the model to published pharmacokinetics/pharmacodynamics profiles separated by response category (CR/PR/NR) from Fraietta et al. 18 using PSO. Model fits (curves: mean of 12 parameter sets; dark shaded areas: middle 90%) agree with both CAR-T and B cell tumor dynamics over time (dots: mean data; light shaded areas: range of data) for each of the three prototypic populations.

DOI