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Presumable mechanisms for activation of antitumor immune response by IDO1 blockade and radiation therapy. 1-MT: 1-methyl tryptophan, RT: radiation, Trp: tryptophan, IDO1: indoleamine 2,3 dioxygenase 1, Kyn: kynurenine, KPM: kynurenine pathway metabolites, LAT1: L-amino acid transporter 1, CTLA-4: cytotoxic T lymphocyte-associated antigen-4, GCN2: general control non-depressive 2 kinase, AHR: aryl hydrocarbon receptor
#Workflow#Flowchart#Illustration#Antitumor Immune Response#IDO1 Blockade#Radiation Therapy#Tryptophan#Kynurenine#Aryl Hydrocarbon Receptor
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