Effects of CXCR4 mutagenesis on CXCL12 binding. Log2enrichment scores reflect CXCL12-GFP binding to cells harboring WT versus mutated CXCR4 (STAR Methods). Statistical testing by Kruskal-Wallis test withpvalues determined by post hoc Dunn test with Bonferroni correction for multiple comparisons.*pvalue < 0.05,***pvalue < 0.001,****pvalue < 0.0001.pvalues for all other pairwise comparisons > 0.05. Boxplot boxes reflect the median (central line), first and third quartiles (box boundaries), and largest/smallest values no further than 1.5x the interquartile range (whiskers). Raw data from Heredia et al.43 See alsoFigures S2andS3.
