Adjusted Kaplan-Meier plot for CVD risk by mRNFL thickness tertiles in UK Biobank. Probability of incident CVD risk was shown over time for participants from UK Biobank with different mRNFL thickness tertiles. Lower tertile represents thinner mRNFL thickness. Plot was based on Cox proportion hazards regression models, adjusted for age, sex, ethnicity, assessment center, household income, Townsend deprivation index, SBP, HbA1c, fasting glucose, BMI, smoking status, drinking status, MVPA, history of hypertension and diabetes, antihypertensive drugs, insulin usage, lipid-lowering drugs, IOP, SER, and image quality score. Compared to participants with highest tertile of mRNFL thickness, CVD risk was comparable for those in the second tertile (HR = 1.16, 95% CI: 0.99-1.36, p = 0.065). The risk of incident CVD was significantly increased for participants in the lowest tertile of mRNFL thickness (HR = 1.18, 95% CI: 1.01-1.38, p = 0.036). CVD, cardiovascular disease; mRNFL, macular retinal nerve fiber layer; HR, hazard ratio; CI, confidence interval
