Structural superposition of active PrRPR, predicted from AF2 inactive PrRPR (AF-P49683-F1), inactive NPY2R (PDB:7DDZ), and active NPY2R (PDB:7YOO) from side (left) and cytoplasmic (right) views. The movement directions of TM6 and TM7 in PrRPR relative to inactive NPY2R are highlighted as red arrows. Inactive NPY2R, active NPY2R, PrRPR, and predictive PrRPR are colored in gray, cyan, orange, and violet, respectively.
