Workflow from Scientific Research

Analysis workflow used to measure the frequencies of mycobacteria-reactive- (Mtb-) or CMV-, EBV- or influenza A (Infl.A)-specific GLIPH2 TCR groups in controllers and progressors. GLIPH2 analysis was performed and the resulting GLIPH2 similarity groups were filtered initially using the criteria listed under Filter 1. TCR similarity groups with significant HLA-allele associations in the progressor/controller cohort were then selected (Filter 2). Similarity groups that were differentially abundant in controllers and progressors bearing the associated HLA-allele were identified (Filter 3).

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