Comparison of serum levels in patients with SS (no CRS n = 2, Grade 1 n = 5, Grade 2 n = 7, Grade 3 n = 1, Grade 4 n = 1) and those with other indications (no CRS n = 15, Grade 1 n = 5, Grade 2 n = 2) across CRS groups. Peak IFNg levels (pg ml -1 ) were significantly greater in patients with CRS (all grades, n = 21) compared with non-CRS ( n = 17) (median, 270.8 pg ml -1 and 47.7 pg ml -1 , respectively; P = 0.00012). Calculated IFNg AUC from days 0 to 21 was significantly greater in patients with CRS compared with non-CRS (median, 1,455.0 pg ml -1 and 467.0 pg ml -1 , respectively; P = 0.00061) (Wilcoxon rank-sum test, two-sided).
