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Highly induced YFPCreNotch1 +/flox (+/-) and YFPCreNotch1 flox/flox (-/-) mice or uninduced control (+/+) mice were treated with DEN and SOR and aged for 28 weeks. For b - d, Notch1 +/+, n = 11; Notch1 +/- n = 10; Notch1 -/-, n = 12.
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