Concentrations of IFN-β, IFN-γ, and KC/GRO measured in forebrain total protein extracts. Total IgM and cytokine concentrations and counts of plasma cells were log10-transformed prior to statistical analysis. Statistical significance (*p <0.05,**p <0.01,***p <0.001,****p <0.0001) was determined using a one-way ANOVA followed by the Tukey-Kramer post hoc test. Symbols represent individual samples, and lines represent the mean and SD. Serum: PBS,n= 5; PB-W1,n= 4; R2lc,n= 6; R2lcΔpks,n= 6. Spleen: PBS,n= 5; PB-W1,n= 12; R2lc,n= 8; R2lcΔpks,n= 8. Forebrain: PBS,n= 6; PB-W1,n= 6; R2lc,n= 5; R2lcΔpks,n= 5. See alsoFigures S5andS7–S9.
