Microscopy from Scientific Research

YFPCreNotch1 flox/flox mice were induced at high dose so mutant cells rapidly covered the esophageal epithelium (−/−). Uninduced YFPCreNotch1 flox/flox mice were used as wild-type controls (+/+). Mice were aged as in e and g and tissue was collected. After sectioning, tissue was stained for basal cell marker KRT14, NOTCH1, proliferation marker Ki67, differentiation markers KRT4 and LOR and with H&E. Images are representative of three mice of each genotype. Scale bars, 30 m.

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