Volcano Plot from Scientific Research

Volcano plot showing individual genes with the effect size and the -log10 P value for TWAS based on the atrial appendage (left) and left ventricular tissues (right) from GTEx. Effect sizes and P values were computed using the MetaXcan software to assess the association between predicted gene expression based on the GTEx data and AF. Bonferroni correction was applied to account for the number of genes tested in each tissue (P < 0.05/10,414 for atrial appendage and <0.05/9,702 for left ventricle). Significant genes are highlighted with red (positive effect of predicted gene expression on AF) and blue (negative effect of predicted gene expression on AF).

DOI