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Native MuSK is a transmembrane tyrosine kinase whose ectodomain comprises three immunoglobulin-like (Ig1–Ig3) and frizzled-like (Fz) domains. MuSK-CAAR comprises the native MuSK ectodomain, followed by a glycine/serine-rich linker, CD8α transmembrane domain (TMD) and CD137-CD3ζ intracellular costimulatory and activation domains.
#Illustration#Workflow#MuSK#Tyrosine Kinase#Ectodomain#Immunoglobulin-like Domains#Frizzled-like Domains#MuSK-CAAR#Transmembrane Domain#Costimulatory Domain#Activation Domain
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