Line Plot from Scientific Research

Nonspecific BITE activity derives from 2C11 Ab to CD3, not from Trp2 TCRm. Trp2-negative EL4 cells were pulsed (+P) or not (–P) with Trp2 peptide and then incubated with mouse T cell blasts at different concentrations of BiTE (BiTE) or 2C11 (2C11) scFv. CFSE and PI double-positive cells were gated and the experiment was triplicated. Dead cell percentage are shown as mean ± s.d. (n = 3 biological replicates).

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