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Principle of integration and analysis approach using MOVE. Individual-level non-omics and multi-omics data were used as input to a VAE. The optimal network hyperparameters were estimated from the summed test set error across all individuals in the test (test likelihood), training reconstruction accuracy, and model stability. Significant drugomics associations were identified by perturbing drug status from no (0) to yes (1) for all individuals that were not already administered the drug.

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