Tumor weights from vehicle or STZ-treated mice ( n = 11 in each group). Data represented mean SEM of technical replicates in a, and biological replicates in c, e, f, h, j, and n = 3 independent experiments were performed in a-h, n = 1 for i, j. Statistical significance was evaluated using two-way ANOVA followed by Tukey’s a, j and Bonferroni’s c post hoc test, and one-way ANOVA followed by Tukey’s post hoc test e, and two-tailed Student’s t -test f, h. * P < 0.05; ** P < 0.01; *** P < 0.001 for column 1 versus others, and # P < 0.05; ## P < 0.01; ### P < 0.001 for column 2 versus column 4, a (from left to right, *** P < 0.0001, *** P < 0.0001, ** P = 0.0024, *** P = 0.001, *** P < 0.0001), c (from left to right, * P = 0.0277, * P = 0.042, * P = 0.0166, * P = 0.0182, P = 0.0556), e (from left to right, ** P = 0.0011, *** P = 0.0005), f (*** P < 0.0001), h (** P = 0.0049), j (from left to right, * P = 0.0487, ** P = 0.008, ** P = 0.0099, # P = 0.0486). Source data are provided in Source Data file.
