cellular proliferation in LG- or HG-treated Met1 cells following vehicle or DAPT treatment. Data represented mean SEM of technical replicates in b-c, e–i, l , and biological replicates in m , and n = 3 independent experiments were performed. Statistical significance was evaluated using two-way ANOVA followed by Bonferroni’s b , e , f , g , h , Dunnett’s c , and Tukey’s i , l , m post hoc tests. * P < 0.05; ** P < 0.01; *** P < 0.001 for column 1 versus other columns and # P < 0.05; ## P < 0.01; ### P < 0.001 for column 2 versus column 4, b (all *** P < 0.0001), c (from left to right, * P = 0.0292, * P = 0.0269, ** P = 0.001, * P = 0.0376, ** P = 0.0026, *** P < 0.0001, ** P = 0.0014), e ( *** P < 0.0001), f ( *** P < 0.0001), g (from left to right, *** P = 0.0005, *** P < 0.0001, *** P < 0.0001), h (from left to right, *** P < 0.0001, *** P = 0.0004, * P = 0.0434), i (from left to right, *** P < 0.0001, ### P < 0.0001, * P = 0.0124, # P = 0.0108, *** P < 0.0001, ### P < 0.0001, *** P < 0.0001, *** P < 0.0001, ### P < 0.0001), l (from left to right, *** P < 0.0001, ### P < 0.0001, ** P = 0.0091, ** P = 0.0014, # P = 0.0116), m ( * P = 0.0191, ## P = 0.0006). Source data are provided in Source Data file.
