Workflow from Scientific Research

Open access visualization of Workflow, Illustration, Antibody Prodrug, Matriptase, Cleavable Substrate
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DOI: 10.1016/j.crmeth.2025.101077

DOI

Schematic representation of the antibody prodrug design, which includes a matriptase-cleavable substrate in the linker region between the antibody scaffold and the masking domain. Upon cleavage by matriptase, the masking domain is removed, activating the antibody. Schematics were created with BioRender.com.

#Workflow#Illustration#Antibody Prodrug#Matriptase#Cleavable Substrate#Linker Region#Masking Domain#Antibody Scaffold

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