Bar Plot from Scientific Research

Multiple-loci model: 5,000 dependent markers of different MAFs that are sampled from different uniform distributions are simulated, which areU(0.01,0.5),U(0.05,0.5),U(0.10,0.5),U(0.15,0.5),U(0.20,0.5),U(0.25,0.5),U(0.30,0.5), andU(0.35,0.5).D′(Lewontin’s measure) is used to depict the LD and is sampled from a uniform distributionU(0.1,0.2)andU(0.5,0.8)to represent low LD (E–H) and high LD (I–L). A total of 2,000 first-degree, second-degree, third-degree, and unrelated pairs are simulated and evaluated. All scenarios are performed in 10 repeats. 95% confidence intervals are given as error bars. The dashed box indicates the MAF threshold considered in following real-data analyses.

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