Box-and-whisker plots comparing nuclei ROI correspondence between input fluorescence and translated H&E images across STABLE and baseline methods. Nuclei ROI segmentations were obtained using Cellpose segmentation models applied to input and translated images. (E) Intersection over union (IoU) scores between input and translated ROIs. Two-sample t tests were performed (n= 72 for each test, representing the number of test samples; n.s.p> 0.05, p 0.05, p< 0.01, and p< 0.001).