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Assessment of lung metastasis on day 31;n= 5 biological replicates. Data are presented as means ± SEM.pvalues were analyzed by two-way ANOVA with Tukeys multiple comparisons (D) or one-way ANOVA with Holm-Sidaks multiple comparisons test (E, H) and two-tailed unpaired Students t test (I). *p< 0.05, ***p< 0.001, ****p< 0.0001.

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