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EcN-IL-15 reshapes the TME and boosts anti-tumor immune responses. Quantification of CD3+T cells, CD4+T cells, CD8+T cells, NK cells, DCs, and macrophages in MC38 tumor tissues; n= 4 biological replicates. Data are presented as means ± SEM unless otherwise specified.p values were analyzed by one-way analysis of variance (ANOVA) with Tukey’s multiple comparisons test (G, K), two-way ANOVA with Tukey’s multiple comparisons test (I), or Mantel-Cox log rank test (J). *p< 0.05, **p< 0.01, ***p< 0.001, ****p< 0.0001; ns, not significant.

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