Protein Structure from Scientific Research

Cartoon representation of the TRPML1 structure (using co-structure with ML-SA52as illustration) in perspective horizontal to the plane of the membrane, where the membrane coordinates were determined by the OPM database,34with notional boundaries highlighted by red and blue circles. The four subunits are colored differently; PI(3,5)P2 molecule binding in site 1 is represented as a green Connolly surface and compound2 in binding site 2 is represented as a magenta Connolly surface.

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