Workflow from Scientific Research

Open access visualization of Workflow, Illustration, Single-Strand Break, Transcription, PARP1
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Citation

DOI: 10.1016/j.celrep.2025.115737

DOI

Upon the formation of an SSB, transcription of immediate-early response genes (IERGs) and paused genes is impaired. PARP1 is then recruited to the break site, where it is ADP-ribosylated. It then ADP-ribosylates other repair proteins such as NuMA and TDP1, facilitating their recruitment to the SSB site to repair the SSB. Once repaired, transcription is restored.

#Workflow#Illustration#Single-Strand Break#Transcription#PARP1#DNA Repair#ADP-ribosylation#NuMA#TDP1

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