Alignment of amino acid sequences of LZY1, LZY2, LZY3, and OsLAZY1 in the region containing the CCL domain (Furutani et al., 2020). Below: identification of the CCL-like domain in C4 from TYLCV and design of C4CCLm1and C4CCLm2mutants; amino acid substitutions relative to the original C4 sequence are indicated in bold coral-colored letters. Numbers indicate the amino acid position in the corresponding proteins.