Manhattan Plot from Scientific Research

Manhattan plot of the results from recessive tests performed. Dashed horizontal lines represent the various p-value cutoffs: genome-wide significance (GWS; p< 5 x 10-8), for a false discovery rate of 5% (FDR5; p< 3.7 x 10-8), and the Bonferroni-corrected cutoff (Bonferroni; p< 5.5 x 10-12). Blue points represent recessive tests passing the genome-wide significance threshold where the recessive p-value is more significant than the additive p-value, and diamonds represent lead variants defined as described in the methods. The clusters containing Bonferroni-significant associations are labeled with the phenotypes with which they are associated.

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