ChIP-seq signal in naive ESCs (black) versus CEpiL cells (pink) from indicated studies, highlighting context-specific binding at P1 and P2, adjacent regions located within the Intron1 element but not the Iee or 5′ element. P1 is occupied by LEF1 and p300, while CTNNB1 (βCAT), TCF3, and HDAC3 occupy P2.
