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Open access visualization of Illustration, Workflow, Promastigote, Haptomonad-like Cells, FAZ34
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A schematic of the parental and FAZ34 null mutant promastigote and haptomonad-like cells based onin vitroobservations. FAZ34 deletion disrupts the anterior cell tip morphology, resulting in the separation of KIAP2 and the flagellar filaments from the anterior cell tip in the promastigote and haptomonad-like cells, with the cell tip positioned further from the adhesion plaque in the latter when compared with parental cells. This is associated with defects in adhesion plaque assembly, with lower levels of KIAP1 and KIAP3 in the plaque and a reduced plaque size, which translates to unstable adhesion in the FAZ34 null mutant. See alsoFigure S6.

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