Heatmap from Scientific Research

Hierarchically clustered heatmap across all HFSC/HFSC progeny clusters showing gene set enrichment of transcripts within each cluster for ISR-related gene sets from the GO database, Reactome Pathway KnowledgeBase, and the literature. Color scales represent the NESs for each gene set compared with rank lists of cKO vs. WT within each Leiden cluster. For GSEA tests where the adjusted p value was greater than 0.25, the NES was set to zero. AA, amino acid; GCN2, general control nonderepressible 2; PERK, protein kinase R-like ER kinase; UPR, unfolded protein response; HRI, heme-regulated eIF2α kinase; ISR, integrated stress response. See Figure S4 for additional data related to this figure.

DOI