Illustration from Scientific Research
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The negatively charged glycocalyx of target and effector cells interferes with an efficient ADCC reaction. Coupling cytotoxic antibodies with sugar-modifying enzymes such as sialidase may allow an optimal ADCC reaction via removing inhibitory sugar residues, including terminal sialic acid residues. Figure created with Biorender.
#Illustration#Glycocalyx#Target Cells#Effector Cells#ADCC Reaction#Cytotoxic Antibodies#Sugar-modifying Enzymes#Sialidase
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