Line Plot from Scientific Research

Proportion of escape mutations seen in over 1,000 strains in Global Initiative on Sharing All Influenza Data (GISAID), as predicted by EVEscape (with and without SARS-CoV-2 sequences), high-throughput DMS experiments across 20 studies (Table S5), or randomly selected RBD mutations. Predicted escape mutations were defined as nonsynonymous, single-nucleotide RBD mutations in the top 5% of escape scores for computational and experimental methods (top 1% and 10% inFigure S4). Points indicate updates to the set of escape mutations based on the availability of a more recent DMS data (blue) or model (red, which includes SARS-CoV-2 sequences available prior to that date). Predictions for the full spike protein (computational) and for each independent experiment and model are provided inFigure S4.

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