Heatmap from Scientific Research

Representative images (K) and quantification (L) of glucose, glucose-6-phosphate (G6P), fructose-1/2,6-bisphosphate (FBP), phosphoenolpyruvate (PEP), lactate, citrate, pyruvate, succinate, malate, fumarate, ribose-5-phosphate (R5P), 6-phosphogluconolactone (6-PG), NADPH, and GSH using MALDI mass spectrometry in WT (n= 6) andPfkfb3-cKO (n= 7) mice at late-stage of EAE (30 days p.i.). The gray matter is indicated in white and the ventral horns in green, which were used for quantification. The rowZscores are shown in the heatmap and the rows are sorted by significance. Unpaired t tests were used for statistical comparison. Scale bar, 500 m. Unless stated otherwise, the Mann-Whitney U test was used for statistical comparisons, and individual data points and means are shown.*p< 0.05,**p< 0.01. See alsoFigures S11andS12.

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