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Five hypoxia-induced transcripts in the brain measured post daily administration of vehicle or HypoxyStat (400 mg/kg) or initiation of continuous 11% O2breathing. This was done after 2 days (plasma Epo, HIF targets) or after 2 weeks (hematocrit, blood glucose).pvalues relative to vehicle. HypoxyStat and inhaled hypoxia have similar effect sizes, whereas GBT-440 is less effective.*p< 0.05,**p< 0.01,***p< 0.001,****p< 0.0001, ANOVA. See alsoFigures S2andS3.

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