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Neutralization sensitivity of the resistant autologous virus SGA14 and its mutants to FD22. The resistant autologous virus SGA14, derived from P27, was engineered by substituting the V2 Loop, Loop D, CD4 BLP, and V5 Loop of HXBc2 Env into SGA14. Sequence variations in the P27 autologous virus relative to the HXBc2 reference are highlighted in red, with reverse mutations indicated in bold and underlined. IC 50 values are represented using a color code: red (<0.1 μg/mL), orange (0.1–1 μg/mL), and yellow (>1 μg/mL). VRC01 was included as a control for comparative analysis.

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