Among all study participants (n = 330), the percentage who had baseline P. falciparum at enrollment before AL administration (study day -14 7) is shown, as detected by 18S qRT-PCR (red line) or TBS microscopy (blue line), followed by the percentage of participants who failed to clear their baseline infections by 18S qRT-PCR or TBS by the day of CIS43LS/placebo administration (day 0) or by scheduled visits thereafter through day 70. For each participant who had infection detected by 18S qRT-PCR at enrollment, subsequent clearance of infection was defined as two consecutive negative 18S qRT-PCR assay results. For seven participants (two in the placebo arm, three in the 10 mg kg -1 arm and two in the 40 mg kg -1 arm), DBS at enrollment were not available for 18S qRT-PCR analysis.
