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In the efficacy trial that began before the 6-month malaria transmission season, participants received a standard 3-day treatment course of AL at enrollment (day -14 ± 7). On day 0 they were randomized and received a single IV infusion of normal saline placebo (n = 110), or CIS43LS at a dose of 10 mg kg -1 (n = 110) or 40 mg kg -1 (n = 110). DBS and TBS were obtained for 18S qRT-PCR and microscopic examination, respectively, at enrollment and on days 0, 1, 3, 7, 14, 21 and 28 and every 2 weeks thereafter for 24 weeks and during unscheduled illness visits when malaria was suspected. DBS from study day 1 were not analyzed by 18S qRT-PCR.

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