Burden of lytic phase proteins, namely, BOLF1. In all panels, the burden of a particular protein in a sample refers to the number of antigens derived from this protein divided by the total number of antigens recognized in this sample, which was calculated for people with (n = 115) or without (n = 201) primary sclerosing cholangitis (PSC). Each dot represents the burden of response against a particular EBV protein in an individual and black lines represent the median across different people, the boxplots represent the IQR and the whiskers represent datapoints within the 1.5 times the IQR range. All statistical comparisons were conducted using the two-sided MannWhitneyWilcoxon test.