Least squares mean (standard error) change in BOLD fMRI parameters for high-fat, high-sugar foods versus non-food objects at week 3. For each scan and each region, the mean of positive voxels was taken within each of the regions separately. The least squares mean was estimated using a MMRMs in all randomized participants who had available data (placebo, n = 33; tirzepatide, n = 31; liraglutide, n = 34). Statistical tests were two-sided at a significance level of 0.05 and no adjustments were made for multiplicity. No positive voxels (food > non-food) were identified for the ventral striatum; therefore, statistical analysis was not done on this region. * P < 0.05 versus placebo (high-fat, high-sugar foods versus non-food objects: medial frontal gyrus, P = 0.0335; cingulate gyrus, P = 0.0306; hippocampus, P = 0.0221; orbitofrontal cortex, P = 0.0321).
