Volcano plot from differential expression analysis from NIVO and COMBO CM-067 analysis (n = 212) showing upregulation of DEGs in the SOD pathway in HG-T. Genes with negative log 2 fold change (log 2 FC) are downregulated in HG-T; genes with positive log 2 FC are upregulated in HG-T. Red points are the significant DEGs in both NIVO NCB and NIVO and COMBO analyses that are present in the SOD pathway. Yellow and blue points are DEGs that are significantly upregulated and downregulated, respectively, in HG-T in both NIVO NCB and NIVO and COMBO analyses. Light gray points are significant DEGs in the NIVO and COMBO analysis that did not overlap with DEGs in the NIVO NCB comparison. Dark gray points are genes that were not significantly differentially expressed and did not overlap between the NIVO NCB comparison and NIVO and COMBO comparison. -log 10-transformed P values derived from negative binomial Wald test in DESeq2.
