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CONSORT diagram for the centers and patients enrolled in the trial. Each center was randomized only after patient recruitment had been completed, aiming for a maximum of 25 patients per center. A 1:1 randomization to intervention (additional education for healthcare professionals) or control (usual approaches to medical education) was performed using a minimization algorithm to account for country and the cluster-level values for the co-primary outcomes at baseline. All centers randomized to the intervention group received the educational program.

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