DEGs from myeloid nuclei within <20 m of A plaques (lecanemab versus nAD). CDR is included as a covariate in the MAST model. n , p - q , nAD = 2; LCMB = 1. g , h , l , m , q , MAST was used to compare expression levels. Covariates included sex, age, CDR and gDNA percentage with sample ID as a random effect ( g and l ); brain region, CDR and gDNA percentage with brain region and sample ID as a random effect ( h and m ); CDR ( q ). i , DESeq2 was used to compare expression levels. Covariates included sex, age, average genes detected, gDNA percentage (AN1792 versus nAD); average genes detected, brain region and gDNA percentage (lecanemab versus nAD). v , Covariates included sex, age, average genes detected and gDNA percentage. g - i , l , m , q , v , P values were FDR adjusted using Benjamini-Hochberg.
