Manhattan Plot from Scientific Research

Clone-specific pseudobulk profile for a representative patient showing detection of the chr. 21amp event in single cells by the CN-calling software numbat. Each of the three plot subpanels defines a CN-defined clone, with the chromosomal location along the x axis. Each subpanel contains two sections; the top section shows the log 2 FC of normalized CN and the bottom panel the parental haplotype frequency (pHF), inferred from haplotype phasing of SNPs genotyped from single-cell transcriptomes. CNA calls are colored by type of alteration (amplification in red, deletion in blue, CNN-LOH in green). The red magnified box highlights the chr. 21amp event.

DOI