Microscopy from Scientific Research

Two representative images of metaphase spreads and interphase cells from bone marrow cells from patient 3 ( e and f ) after FISH with two probes targeting the amplified region on chr. 21q22.2 (green) and a control region on chr. 22q12.2 (red). The chr. 21 amplification event is intrachromosomal. The experiment was performed once and 30 metaphase cells examined. Images were taken at ×1,000 magnification; scale bars, 20 m.

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