Workflow from Scientific Research

Schematic illustration of miniQuant to estimate gene isoform abundance. Left, miniQuant leverages the strengths of long and short reads. Middle, miniQuant-L and miniQuant-H are developed for two data scenarios. The miniQuant-H integrates the likelihood of both long and short reads with gene- and data-specific weight c , which is determined by a machine learning model with data and gene structure features (for example, K-value) as input. Right, gene isoform abundances estimated from the hybrid likelihood using the EM algorithm.

DOI