Data are presented as estimated values of ratio of true effect sizes with 95% central bootstrapped CIs. {beta }_{j}^{i} values refer to mean increase in phenotype per PGS unit increase for local ancestry j and global ancestry i (see Methods for further details). Colors of {beta }_{j}^{i} : blue, European; purple, projected to 100% African ancestry; red, African ancestry. Black rows represent individual UKB traits; the first standing height row uses an existing PGS 16 ; the dark green rows show combined estimates. Columns (left to right) estimate rho for ‘all’ 8,003 African-ancestry individuals, rho for individuals of 100% projected African ancestry and (as expected, reduced) predictive power for African-ancestry segments. From top to bottom, the rows above and below the first horizontal dashed line represent non-molecular and molecular traits and rows above and below the second dashed line represent individual traits and their weighted average estimation. Vertical dotted lines: grey lines indicate rho = 0.5 (left of the red dotted lines) and rho = 1.5 (right of the red dotted lines); red lines indicate rho = 1. ALP, alkaline phosphatase; FVC, forced vital capacity; HDL, high-density lipoprotein; IGF1, Insulin-like growth factor-1; LDL, low-density lipoprotein.
