Layer-specific density of Aβ + mask (shown in Fig. S8.i ) generated from the 4G8 Aβ channel to identify plaques and their total areas within the sections of CtrlCV (n = 6), CtrlTREM2 (n = 6), AlzCV (n = 18), and AlzTREM2 (n = 13) samples. Quantification was performed on three ROIs acquired from a single section of each sample and pooled together before performing statistical analyses between groups. Statistical significance estimates were calculated with Dirichlet regression. Boxplots show median (middle line), interquartile range (box) and variability outside of the first and third quartiles (lines extending from box). P values are indicated as: non-significant, ns, p > 0.05; * p <= 0.05; ** p <= 0.01; *** p <= 0.001; **** p <= 0.0001. Source data are provided as a Source Data file.
