Aggregated MCC for the evaluated pathway-level DC methods, including different DRaCOoN configurations, across a spectrum of case-to-total sample ratios. The x-axis represents the ratio of case samples to the total number of samples, ranging from 0.1 to 0.9. Each cell in the heatmap contains the mean MCC score for an algorithm at a specific case-to-total sample ratio, averaged over five runs and five simulations, and the five different perturbation approaches. The algorithms are ranked by their mean performance across all scenarios, and the color gradient reflects the MCC value, with blue intensity indicating higher performance
