Microscopy from Scientific Research

Spatial mapping of the clones from the phylogenetic tree onto an H&E-stained photomicrograph of the patients liver biopsy, with SERPINA1 mutant clones colored to match the tree shown in a . Each dot signifies a microdissection, with solid black dots indicating LCM microdissections harboring a SERPINA1 mutation. For WGS samples, clonal cell fraction is depicted, with a fully filled disk signifying all clones detected in the LCM sample and SERPINA1 mutant cell fraction depicted by the degree of disk filling. Dashed lines indicate SERPINA1 mutations identified exclusively in WES samples. Nodules are color-highlighted, whereby all microdissections within the nodule contain the same SERPINA1 mutant clone.

DOI