Heatmap from Scientific Research

Comparative analysis of TP53 isoform- 8 (199aa; middle) and the corresponding subsequence of the primary isoform, isoform- 1 (133-331; top). The difference matrix (bottom) highlights mutations with increased effect in isoform- 8: missense mutations from ClinVar predicted to be pathogenic in both isoforms (blue), mutations predicted to be pathogenic in both isoforms but not reported in ClinVar (green), and mutations predicted to be pathogenic only in isoform- 8 and not reported in ClinVar (cyan)

DOI